Clinical Applications
For biological samples — including urine, whole blood, plasma, and serum — the question often asked is: What is the best way to prepare these samples for analysis by ICP-MS? Find answers to this question and other materials on clinical applications here.
Preparing Biological Samples for Elemental Analysis by ICP-MS
For biological samples — including urine, whole blood, plasma, and serum — the question often asked is: What is the best way to prepare these samples for analysis by ICP-MS?
Multi-element Analysis of Biological Materials by ICP-MS using Alkali Dilution
ICP-MS is today the instrument of choice when it comes to elemental analysis of biological materials including urine, whole blood, plasma, and serum. The fast, multi-element capability of the technique and wide dynamic range are key benefits that allow the measurement of major, minor, essential, and toxic elements, covering the concentration range from sub parts-per-trillion (ppt) to percent levels in a single analysis. This places greater pressure on the sample preparation procedure…
Analysis of Low Level Beryllium in Urine Using the PlasmaQuant® MS
The human health effects of beryllium from low environmental exposures are relatively unknown, although higher exposures particularly through inhalation can lead to several adverse medical conditions. Beryllium is chemically similar to magnesium and, therefore, can displace it from enzymes, which causes them to malfunction. Inhalation of beryllium dust or fumes can lead to an incurable inflammation of the lungs called Chronic Beryllium Disease (CBD) or berylliosis. Berylliosis can occur within a few months or many years (10 years in some cases) after exposure to high levels of beryllium (greater than 0.2 µg/m3)…
Determination of As Species in Urine Samples Using the PlasmaQuant® MS Elite
The monitoring of arsenic species in urine can greatly assist with risk-based toxicity assessments where total arsenic determinations are often unsuitable.
For example; when elevated arsenic levels in urine are detected due to the consumption of non-toxic organic arsenic compounds commonly found in seafood…
Iron Isotope Ratios in Human Whole Blood by PlasmaQuant® MS
ICP-MS is now a well-established technique for use in human studies because it can determine both the total elemental content and isotopic ratios with sufficient precision and accuracy in a single analytical run. Stable Fe isotope ratio determinations by ICP-MS in blood have attracted much interest in recent years…